Dr Phillip Lowe
EPSRC Research Fellow
Selected publications
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Open access
Exploring linear mono-, bis- and tris-acetylene containing agonists of the human olfactory receptor OR1A1
Liu, W., Dobson, L. S., Zhang, C., Sun, J., Lowe, P. T., Liu, Y., Zhuang, H. & O'Hagan, D., 16 Jun 2025, (E-pub ahead of print) In: Journal of Medicinal Chemistry. Ahead of Print, 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Staphylococcus aureus COL: an atypical model strain of MRSA that exhibits slow growth and antibiotic tolerance due to a mutation in PRPP synthetase
Stevens, C. E., Deventer, A. T., Johnston, P. R., Lowe, P. T., Boraston, A. B. & Hobbs, J. K., 9 Jun 2025, (E-pub ahead of print) In: Molecular Microbiology. Early View, p. 1-15 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
Exploring fluorinase substrate tolerance at C-2 of SAM
Lowe, P. T., Lüddecke, I. T. & O'Hagan, D., 17 Nov 2024, In: ChemBioChem. 7 p., e202400861.Research output: Contribution to journal › Article › peer-review
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Open access
Halogenated adenine and adenosine natural products in Streptomyces sp. JCM9888
Chen, Y., Lowe, P., Deng, H. & O'Hagan, D., 30 Oct 2024, (E-pub ahead of print) In: European Journal of Organic Chemistry. Early View, 9 p., e202400578.Research output: Contribution to journal › Article › peer-review
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Open access
4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics
Lowe, P. T. & O’Hagan, D., 7 Jan 2023, In: Chemical Society Reviews. 52, 1, p. 248-276 29 p.Research output: Contribution to journal › Review article › peer-review
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Open access
Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro
Kittilä, T., Calero, P., Fredslund, F., Lowe, P. T., Tezé, D., Nieto-Domínguez, M., O’Hagan, D., Nikel, P. I. & Welner, D. H., 27 Jan 2022, (E-pub ahead of print) In: Microbial Biotechnology. Early View, 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
Calero, P., Volke, D. C., Lowe, P., Gotfredsen, C. H., O'Hagan, D. & Nikel, P. I., 7 Oct 2020, In: Nature Communications. 11, 11 p., 5045.Research output: Contribution to journal › Article › peer-review
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Open access
An engineered E. coli strain for direct in vivo fluorination
Markakis, K., Lowe, P. T., Davison-Gates, L., O'Hagan, D., Rosser, S. J. & Elfick, A., 3 Mar 2020, (E-pub ahead of print) In: ChemBioChem. Early ViewResearch output: Contribution to journal › Article › peer-review
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Open access
An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange
Lowe, P. T., Cobb, S. L. & O'Hagan, D., 28 Aug 2019, In: Organic & Biomolecular Chemistry. 17, 32, p. 7493-7496 4 p.Research output: Contribution to journal › Article › peer-review
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A role for fluorine in flavours, fragrances and pheromones?
Lowe, P. T. & O'Hagan, D., 15 Nov 2019, (E-pub ahead of print) In: Journal of Fluorine Chemistry. In pressResearch output: Contribution to journal › Article › peer-review